Aspirin Use and Survival After Diagnosis of Colorectal Cancer

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Aspirin use and survival after diagnosis of colorectal cancer.

CONTEXT Aspirin reduces risk of colorectal neoplasia in randomized trials and inhibits tumor growth and metastases in animal models. However, the influence of aspirin on survival after diagnosis of colorectal cancer is unknown. OBJECTIVE To examine the association between aspirin use after colorectal cancer diagnosis on colorectal cancer-specific and overall survival. DESIGN, SETTING, AND P...

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Aspirin use after a prostate cancer diagnosis and cancer survival in a prospective cohort.

Experimental and clinical data suggest that aspirin and other nonsteroidal inflammatory drugs may delay the progression of prostate cancer through inhibition of the COX pathway and its effects on cellular proliferation, apoptosis, and angiogenesis. Epidemiologic data support a reduced risk of prostate cancer incidence with aspirin use, yet no evidence exists about whether aspirin after diagnosi...

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Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.

IMPORTANCE Use of aspirin (which inhibits platelet function) after a colon cancer diagnosis is associated with improved overall survival. Identifying predictive biomarkers of this effect could individualize therapy and decrease toxic effects. OBJECTIVE To demonstrate that survival benefit associated with low-dose aspirin use after a diagnosis of colorectal cancer might depend on HLA class I a...

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Physical activity and survival after colorectal cancer diagnosis.

PURPOSE Physically active individuals have a lower risk of developing colorectal cancer but the influence of exercise on cancer survival is unknown. PATIENTS AND METHODS By a prospective, observational study of 573 women with stage I to III colorectal cancer, we studied colorectal cancer-specific and overall mortality according to predefined physical activity categories before and after diagn...

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ژورنال

عنوان ژورنال: JAMA

سال: 2009

ISSN: 0098-7484

DOI: 10.1001/jama.2009.1112